Junjie Cheng, Jiadong Li,Bin Miao, Jine Wang, Zhengyan Wu, Dongmin Wu, and Renjun Pei, Ultrasensitive detection of Hg21 using oligonucleotide-functionalized AlGaN/GaN high electron mobility transistor.
APPLIED PHYSICS LETTERS,2014, doi: 10.1063/1.4894277
Abstract: An oligonucleotide-functionalized ion sensitive AlGaN/GaN high electron mobility transistor (HEMT) was fabricated to detect trace amounts of Hg 2+. The advantages of ion sensitive AlGaN/GaN HEMT and highly specific binding interaction between Hg 2+ and thymines were combined. The current response of this Hg 2+ ultrasensitive transistor was characterized. The current increased due to the accumulation of Hg 2+ ions on the surface by the highly specific thymine-Hg2+-thymine recognition. The dynamic linear range for Hg 2+ detection has been determined in the concentrations from 10−14 to 10−8 M and a detection limit below 10−14 M level was estimated, which is the best result of AlGaN/GaN HEMT biosensors for Hg 2+ detection till now.
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